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Updated: Jul 12, 2026

Preoxygenation Techniques for Tracheal Intubation in Critically Ill Adults Utilizing Oxygen Mask and Noninvasive Ventilation
Published on: December 5, 2025
Standard preoxygenation vs two techniques in children
Bruno Chiron1, Christophe Mas, Martine Ferrandière
1Service d'Anesthésie-Réanimation, Centre Pédiatrique Gatien-de-Clocheville CHRU de Tours, Tours, France. b.chiron@voila.fr
Insights
Tidal volume breathing for 3 minutes is the most effective preoxygenation method for children, achieving 90% expired oxygen concentration faster than other techniques. This study evaluated fractional expired oxygen concentration (F(ET)O(2)) to compare methods.
Area of Science:
- Anesthesiology
- Pediatric Medicine
- Respiratory Physiology
Background:
- Preoxygenation is crucial in pediatric anesthesia but lacks thorough assessment.
- Fractional expired oxygen concentration (F(ET)O(2)) serves as a key monitor for preoxygenation effectiveness.
Purpose of the Study:
- To prospectively compare three distinct preoxygenation techniques in children.
- To measure and compare the F(ET)O(2) achieved by each technique.
Main Methods:
- Twenty children (aged 6-15 years) participated in the study.
- F(ET)O(2) was measured during three randomized preoxygenation methods: tidal volume breathing (TV x 3 min), four deep breaths (4 DB), and eight deep breaths (8 DB).
- Baseline F(ET)O(2) was recorded, and measurements were taken after 3 minutes of each technique.
Main Results:
- Tidal volume breathing for 3 minutes (TV x 3 min) achieved F(ET)O(2) ≥ 90% in 79% of cases within 74 seconds.
- The four deep breaths (4 DB) technique achieved F(ET)O(2) ≥ 90% in only 11% of cases.
- The eight deep breaths (8 DB) technique achieved F(ET)O(2) ≥ 90% in 68% of cases.
Conclusions:
- Tidal volume breathing for 3 minutes is the most efficient preoxygenation technique in children.
- This method reliably achieves the target F(ET)O(2) of ≥ 90%.
Background:
Preoxygenation is recommended in pediatric anesthesia but it has been poorly assessed. Fractional expired oxygen concentration (F(ET)O(2)) is a preoxygenation monitor. The aim of this prospective study in children was to compare three techniques of preoxygenation by the measurement of F(ET)O(2).
Methods:
Twenty children (6-15 years) were included. F(ET)O(2) was measured with the child in a supine position, holding the face mask. The F(ET)O(2) value was measured after 3 min of calm breathing of room air (baseline) and during the three preoxygenation techniques performed in random order: 3 min of tidal volume breathing using an O(2) flow of 9 l x min(-1) (TV x 3 min)--four deep breaths within 30 s using an O(2) flow of 15 l x min(-1) (4 DB)--eight deep breaths within 1 min using an O(2) flow of 15 l x min(-1) (8 DB). Between each technique, at least 5 min breathing room air was allowed to return to baseline F(ET)O(2). Fisher's exact test was used and P < 0.05 was considered significant.
Results:
Twenty children were studied (age: 11.5 +/- 3 years, weight: 42 +/- 21 kg). The F(ET)O(2) > or = 90% was found to be 79% in 74 +/- 40 s with TV x 3 min, 11% with 4 DB, and 68% with 8 DB.
Conclusions:
In children, Vt x 3 min is the most efficient preoxygenation technique to reach F(ET)O(2) > or = 90%.
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