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Related Experiment Videos

Methicillin-resistant Staphylococcus aureus corneal ulcers.

R A Eiferman1, K P O'Neill, N A Morrison

  • 1Department of Ophthalmology & Visual Science, University of Louisville, Kentucky.

Annals of Ophthalmology
|November 1, 1991
PubMed
Summary
This summary is machine-generated.

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Topical vancomycin eye drops are effective for corneal ulcers caused by methicillin-resistant Staphylococcus aureus (MRSA). Vancomycin should be considered over cephalosporins for treating corneal ulcers due to MRSA and Staphylococcus epidermidis.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Microbiology

Background:

  • Corneal ulcers are a significant cause of vision loss.
  • Gram-positive cocci are common pathogens in bacterial keratitis.
  • Standard antibiotic treatments may fail against resistant bacterial strains.

Observation:

  • Three patients presented with corneal ulcers and gram-positive cocci on initial cultures.
  • Initial treatment with topical fortified aminoglycosides and cephalosporins was ineffective.
  • Subsequent cultures identified methicillin-resistant Staphylococcus aureus (MRSA) as the causative agent.

Findings:

  • The isolated methicillin-resistant Staphylococcus aureus was susceptible only to topical vancomycin eye drops.
  • This suggests vancomycin's potential efficacy in treating resistant bacterial keratitis.

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  • The microbiologic spectrum of MRSA and Staphylococcus epidermidis is similar.

    • Implications:

    • Vancomycin eye drops should be considered as a primary treatment option for corneal ulcers.
    • This recommendation is particularly relevant when methicillin-resistant Staphylococcus aureus or Staphylococcus epidermidis is suspected or confirmed.
    • This approach may improve treatment outcomes and prevent vision loss in cases of antibiotic-resistant bacterial keratitis.