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New calogenin glycosides from Hoodia gordonii
Rahul S Pawar1, Yatin J Shukla, Ikhlas A Khan
1National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, University, MS 38677, USA.
Abstract:
Ten new pregnane glycosides (1, 3-11) were isolated from organic extracts of aerial parts of Hoodia gordonii, which is sold as an appetite suppressant herbal supplement. The aglycone was identified as calogenin, based on the spectroscopic data of products obtained upon chemical and enzymatic degradation of parent glycoside. The structures of the glycosides were established by chemical degradation studies and extensive spectroscopic techniques that included one-dimensional and two-dimensional NMR.
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