Related Experiment Video
Updated: Jul 12, 2026

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
Published on: February 10, 2023
Thrombophilia and venous thromboembolism: implications for testing
Danny M Cohn1, Sara Roshani, Saskia Middeldorp
1Academic Medical Center, Department of Vascular Medicine, Amsterdam, The Netherlands.
Understanding venous thromboembolism (VTE) has advanced, revealing thrombophilic defects in half of patients. This review examines the benefits and drawbacks of thrombophilia testing for VTE management.
Area of Science:
- Hematology
- Clinical Medicine
- Genetics
Background:
- Venous thromboembolism (VTE) etiology knowledge has significantly increased.
- Thrombophilic defects are identified in approximately 50% of VTE patients.
- Widespread thrombophilia testing is common, but therapeutic implications remain unclear.
Purpose of the Study:
- To review established hereditary and acquired thrombophilic defects.
- To discuss the advantages and disadvantages of thrombophilia testing in VTE.
- To explore the potential usefulness and implications of thrombophilia screening.
Main Methods:
- Literature review of established thrombophilic abnormalities.
- Analysis of pros and cons of thrombophilia testing in VTE patients.
- Discussion of diagnostic criteria and clinical relevance.
Main Results:
- Several hereditary and acquired thrombophilic defects are known to increase VTE risk.
- Testing identifies thrombophilia in a substantial proportion of VTE cases.
- The clinical utility and impact on treatment decisions require further clarification.
Conclusions:
- Thrombophilia testing is prevalent but its therapeutic consequences in VTE management are debated.
- Understanding specific thrombophilic defects is crucial for risk assessment.
- Further research is needed to establish definitive guidelines for thrombophilia testing in VTE.
More Related Videos
08:01The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
Published on: February 27, 2026
08:50Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis
Published on: January 9, 2026
Related Concept Videos
Venous Thrombosis III: Interprofessional Care
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
Venous Thrombosis I: Introduction
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Venous Thrombosis IV: Nursing Management
Pulmonary Embolism I: Introduction