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Frequent symptoms after DTPP vaccinations
P L Verschoor1, J T Wilschut, G A de Jonge
1Department of Paediatrics, Free University Amsterdam, The Netherlands.
Archives of Disease in Childhood
|December 1, 1991
Summary
Minor reactions are common after diphtheria, tetanus, pertussis, and poliomyelitis (DTPP) vaccinations in infants. Fever, local reactions, and crying frequently occur, with increased risk upon repeat inoculations.
Area of Science:
- Pediatrics
- Immunology
- Public Health
Background:
- The diphtheria, tetanus, pertussis, and poliomyelitis (DTPP) vaccine is a crucial component of infant immunization schedules.
- Understanding the incidence and patterns of minor reactions is essential for parental reassurance and vaccine acceptance.
Purpose of the Study:
- To prospectively evaluate the frequency, associations, and recurrence risk of minor adverse reactions following DTPP vaccinations in infants.
- To characterize common symptoms such as fever, local reactions, crying, and general disturbances.
Main Methods:
- Prospective observational study involving 540 infants receiving 2026 DTPP inoculations in the Netherlands.
- Parental reporting of minor reactions including fever (≥38.0°C), local site reactions, increased crying, and general symptoms (e.g., altered sleep/eating patterns, vomiting, drowsiness).
Main Results:
- Minor reactions were highly prevalent, with fever (67.7%), local reactions (66.2%), and increased crying (64.4%) reported after a majority of inoculations.
- Over 80% of inoculations were associated with at least one general symptom, and only 4.4% had no reported minor reaction.
- Fever was significantly associated with local reactions, crying, and multiple general symptoms. Recurrence of fever, redness, and crying increased with subsequent doses if previously experienced.
Conclusions:
- Minor reactions are common but generally mild following DTPP vaccination in infants.
- The study highlights the high incidence of expected reactions and identifies factors associated with their occurrence and recurrence, aiding in managing parental concerns.