Related Experiment Video
Updated: Aug 9, 2026

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
Published on: February 14, 2022
Pressure-controlled inverse-ratio ventilation
The routine use of PCIRV in adult critical illness remains an area of considerable controversy and debate. This stems in large part from a lack of well-controlled studies demonstrating improved patient outcome over conventional mechanical ventilation techniques. Although it is unlikely that clinicians will stop using PCIRV until such data are available, nurses and other caregivers should exercise caution whenever this form of therapy is employed.
The routine use of PCIRV in adult critical illness remains an area of considerable controversy and debate. This stems in large part from a lack of well-controlled studies demonstrating improved patient outcome over conventional mechanical ventilation techniques. Although it is unlikely that clinicians will stop using PCIRV until such data are available, nurses and other caregivers should exercise caution whenever this form of therapy is employed.
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