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Speech disorders in systemic amyloidosis.

E I Burroughs1, A E Aronson, J R Duffy

  • 1Section of Speech Pathology, Mayo Clinic, Rochester.

The British Journal of Disorders of Communication
|August 1, 1991
PubMed
Summary
This summary is machine-generated.

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Systemic amyloidosis frequently causes speech disorders, particularly affecting voice quality and pitch. Laryngeal examinations revealed vocal fold abnormalities, but direct amyloid deposits were not consistently found.

Area of Science:

  • Speech-Language Pathology
  • Otorhinolaryngology
  • Internal Medicine

Background:

  • Systemic amyloidosis is a rare disease characterized by amyloid protein deposition in various organs.
  • Speech and voice disorders can be manifestations of systemic amyloidosis, but their prevalence and specific characteristics require further definition.

Purpose of the Study:

  • To comprehensively characterize the spectrum of speech and voice disorders associated with primary systemic amyloidosis.
  • To investigate the laryngeal findings in patients with systemic amyloidosis and their correlation with speech abnormalities.

Main Methods:

  • A cohort of 59 patients with histologically confirmed primary systemic amyloidosis was evaluated.
  • Speech and voice parameters, including quality, pitch, resonance, and articulation, were assessed.

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  • Laryngeal examinations were performed on a subset of patients to identify structural abnormalities.

    • Main Results:

    • Abnormal voice quality was observed in 81% of patients, and abnormal pitch in 43%.
    • Laryngeal examination revealed vocal fold abnormalities such as bowing, edema, and thickening in 22 patients.
    • Macroglossia and submandibular swelling were present in 17% and 10% of patients, respectively.

    Conclusions:

    • Abnormal phonation and voice quality are common signs of systemic amyloidosis.
    • While laryngeal changes are frequent, direct evidence of amyloid deposits in the vocal folds was not consistently documented.
    • Further research is needed to elucidate the precise mechanisms linking amyloidosis to dysphonia.