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Related Experiment Videos

Miniaturized heart-lung machine.

I Krueger1, F Ghussen, W Isselhard

  • 1Department of Cardiovascular Surgery, University of Cologne, Germany.

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
|January 1, 1991
PubMed
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Researchers developed a miniaturized heart-lung machine for small animals. This reliable and efficient system features low blood trauma and high oxygen uptake, making it ideal for preclinical research.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Technology
  • Small Animal Research

Background:

  • Developing effective cardiopulmonary bypass systems for small animal models is crucial for preclinical research.
  • Existing systems may be too large or complex for precise application in small animal studies.
  • There is a need for a compact, efficient, and minimally traumatic heart-lung machine for research purposes.

Purpose of the Study:

  • To design and evaluate a novel miniaturized heart-lung machine suitable for small animal research.
  • To assess the system's efficiency in heat transfer and oxygenation.
  • To quantify the level of blood trauma induced by the device during perfusion.

Main Methods:

  • The system was constructed using commercially available roller pumps, a flexible heat exchanger, a newly devised bubble oxygenator, and polyethylene cannulas and silicone tubes.

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  • Priming volumes were determined, ranging from 4.7 to 16.7 mL.
  • In vitro perfusion studies were conducted over 60 minutes to measure heat transfer coefficients, oxygen uptake, and plasma hemoglobin concentrations.

    • Main Results:

    • The miniaturized heart-lung machine demonstrated efficient heat transfer with coefficients from 0.96 to 0.31 at flow rates of 1-20 mL/min.
    • High oxygen uptake was observed (0.061 mL O2/min mL blood-1).
    • Minimal blood trauma was indicated by low plasma hemoglobin levels (47.5 +/- 5.0 mg/dL after 60 min).

    Conclusions:

    • The developed miniaturized heart-lung machine is simple, reliable, and efficient.
    • The system is well-suited for cardiopulmonary bypass in small animal models.
    • This technology offers a valuable tool for advancing preclinical cardiovascular research.