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Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
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Published on: June 29, 2013

Progesterone retards postpartum involution of the rabbit myometrium

F R Goodall

    Science (New York, N.Y.)
    |April 15, 1966
    PubMed

    Postpartum involution of the uterus was significantly reduced in rabbits by immediate and repeated injections of progesterone. Progesterone had no effect if the injections commenced 24 hours after delivery. The decrease in concentration of progesterone that accompanies birth results in release of proteolytic and other degradative enzymes from subcellular particles; these enzymes cause the involution, and, once the enzymes are released into the cellular milieu, progesterone has no effect.

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