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The rat thymidine kinase gene 5' region: evolution of a promoter
S S Arcot1, V L Traina-Dorge, P L Deininger
1Department of Biochemistry and Molecular Biology, Louisana State University Medical Center, New Orleans 70112.
Abstract:
The nucleotide sequence of the rat thymidine kinase (tk) gene 5' region was determined and compared to the 5' sequences of the tk gene from mouse, human, hamster and chicken. This analysis revealed the highest degree of homology to be between the rat and the mouse sequences and correspondingly greater sequence variation relative to the other species. There has apparently been an especially high rate of change in regions that have been demonstrated to be protein binding regions in some of these promoters. This has led to changes in the potential transcription factors bound by some of these promoters.