Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

PET scanning in partial epilepsy.

J Engel1

  • 1Department of Neurology, UCLA School of Medicine 90024.

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
|November 11, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outcomes in 248 patients who had diagnostic evaluations for epilepsy surgery.

Lancet (London, England)·1995
Same author

The C-terminal portion of BM-40 (SPARC/osteonectin) is an autonomously folding and crystallisable domain that binds calcium and collagen IV.

Journal of molecular biology·1995
Same author

The function of the NC1 domains in type IV collagen.

The Journal of biological chemistry·1995
Same author

Management perspectives. I am the nurse manager in a midsize hospital.

Nursing spectrum (D.C./Baltimore metro ed.)·1995
Same author

Electron microscopic evidence for a mucin-like region in chick muscle alpha-dystroglycan.

FEBS letters·1995
Same author

Selective chain recognition in the C-terminal alpha-helical coiled-coil region of laminin.

Journal of molecular biology·1995
Same journal

Practice Patterns and Care Gaps in Lennox Gastaut Syndrome: A call for Action.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2026
Same journal

Isolated Achiasma Discovered at Age 86: A Rare Cause of see-saw nystagmus and bitemporal hemianopia.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2026
Same journal

Post-Stroke Parakinesia Brachialis Oscitans: Clinical Insights from a Case Series.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2026
Same journal

A Neuronal Perspective.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2026
Same journal

Diagnostic efficacy, costs, and safety of portable ultra-low field MRI in brain imaging: a systematic review.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2026
Same journal

Chronology of Non-Motor Symptoms in 100 Patients with Advanced PD of 10 Years' Duration: Pre- versus Post-Motor Period.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2026
See all related articles

Positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) helps identify hypometabolism in epilepsy patients, guiding surgical planning. SPECT may offer insights during seizures when FDG-PET is challenging.

Area of Science:

  • Neuroscience
  • Medical Imaging
  • Epileptology

Background:

  • Positron emission tomography (PET) is crucial for epilepsy research.
  • 18F-fluorodeoxyglucose (FDG) is commonly used to measure glucose metabolism in the brain.
  • Identifying the epileptogenic zone is key for surgical treatment of refractory epilepsy.

Purpose of the Study:

  • To evaluate the utility of FDG-PET in localizing the epileptogenic zone in patients with refractory partial seizures.
  • To explore the role of FDG-PET in surgical planning, particularly in cases requiring hemispherectomy or extensive resections.
  • To compare the utility of PET and SPECT in capturing seizure-related metabolic changes.

Main Methods:

  • Utilized 18F-fluorodeoxyglucose (FDG) PET scans to assess local cerebral metabolic rate for glucose.

Related Experiment Videos

  • Correlated hypometabolic zones identified by FDG-PET with epileptogenic regions.
  • Considered single photon emission computed tomography (SPECT) for ictal scan acquisition.

    • Main Results:

    • Over 70% of patients with medically refractory partial seizures showed interictal hypometabolism corresponding to the epileptogenic zone.
    • Hypometabolism frequently involved the temporal lobe in mesial temporal lobe epilepsy.
    • FDG-PET provided supporting evidence for normal contralateral hemisphere function in pediatric surgical candidates.

    Conclusions:

    • FDG-PET is a valuable tool for identifying hypometabolic regions in epilepsy, aiding in the localization of the epileptogenic zone.
    • While FDG-PET reflects functional deficits, electrophysiological confirmation of epileptogenicity is necessary.
    • SPECT may be more suitable for ictal imaging compared to FDG-PET due to technical challenges with the latter during seizures.