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Related Experiment Videos

Sickle cell glomerulopathy with focal segmental glomerulosclerosis.

R R Verani1, S B Conley

  • 1Department of Pathology and Laboratory Medicine, University of Texas Medical School, Houston.

Child Nephrology and Urology
|January 1, 1991
PubMed
Summary

Sickle cell disease can cause kidney damage, including focal segmental glomerulosclerosis (FSGS). Early ultrastructural changes in the glomerulus may precede FSGS development in young patients with sickle cell glomerulopathy.

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Area of Science:

  • Nephrology
  • Hematology
  • Pathology

Background:

  • Sickle cell disease (SCD) is a known cause of glomerulopathy.
  • Focal segmental glomerulosclerosis (FSGS) is a specific lesion associated with SCD.
  • Patients with SCD and FSGS often have a worse prognosis, including persistent proteinuria and end-stage renal disease.