[Predicting the genome response of the somatic cells of divers to hyperoxic medium]

Cytogenetical consequences of high oxygen pressure action (HOB) have been studied in professional and nonprofessional divers after deepening. Blood samples of subject from both groups were treated with HBO in vitro to compare individual reaction of the somatic cells genome to HOB. The present study reveals that HBO increases the level of chromosome aberrations, and individual response to HBO differs. There is a correlation between the level of chromosome aberrations in vivo and in vitro. This indicates that blood treatment in vitro can reveal the sensitivity of the genome in human before HBO treatment. According to the data in vitro 2 groups of the genome response to HBO: up to 20% and higher than 20% aberrations are distinguished.