Related Experiment Video

Updated: Jul 12, 2026

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches
13:36

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

Published on: May 6, 2015

[Prevalence of adenovirus antigens in children presenting with acute diarrhoea]

I Fodha1, A Chouikha, J Dewar

  • 1Laboratoire de Bactériologie-Virologie, Centre Hospitalier Universitaire Sahloul, Sousse, Tunisie.

Medecine Tropicale : Revue Du Corps De Sante Colonial
|September 6, 2007
PubMed

Insights

Adenovirus causes viral diarrhoea in young children globally. In Tunisia, enteric adenovirus types 40/41 were identified in over half of adenovirus-positive paediatric stool samples, highlighting their role in childhood illness.

Area of Science:

  • Virology
  • Epidemiology
  • Pediatrics

Context:

  • Viral diarrhoea is a significant global health concern for children.
  • Four main viral categories (rotavirus, astrovirus, adenovirus, calicivirus) are clinically important.
  • Adenovirus, particularly species F types 40 and 41, is a key pathogen.

Purpose:

  • To investigate the prevalence and role of adenovirus, specifically enteric adenovirus types 40/41, in acute paediatric diarrhoea in Tunisia.
  • To assess the clinical symptoms associated with adenovirus infections in children.
  • To evaluate the utility of diagnostic techniques for viral gastroenteritis.

Summary:

  • A retrospective study analyzed 638 stool samples from Tunisian children under 5 with acute diarrhoea (Oct 2003-Sep 2005).
  • Immunoenzymatic assay (EIA) and ELISA detected adenovirus in 6% of samples; 57% of these were species F adenovirus types 40/41.
  • Diarrhoea, vomiting (89%), fever (53%), and respiratory issues (32%) were common symptoms.

Impact:

  • Enteric adenoviruses are significant contributors to paediatric diarrhoea in Tunisia.
  • Implementing rapid viral diagnostic methods in hospitals can improve patient management.
  • Reducing unnecessary antibiotic use through accurate viral diagnosis is crucial for effective healthcare.

More Related Videos

Swab Sampling Method for the Detection of Human Norovirus on Surfaces10:03

Swab Sampling Method for the Detection of Human Norovirus on Surfaces

Published on: February 6, 2017

Related Concept Videos

Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Cholera01:25

Cholera

Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...