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Updated: Jul 12, 2026
08:31
Optimized Griess Reaction for UV-Vis and Naked-eye Determination of Anti-malarial Primaquine
Published on: October 11, 2019
[Tolerance of amodiaquine]
1UR 77, IRD, Dakar, Sénégal. jean-marc.bouchez@sanofi-aventis.com
Medecine Tropicale : Revue Du Corps De Sante Colonial
|September 6, 2007
Summary
Amodiaquine, an antimalarial, can cause toxicity but is now accepted for treatment due to chloroquine resistance. Its combination with artesunate is recommended for Plasmodium falciparum malaria.
Area of Science:
- Pharmacology and Toxicology
- Infectious Diseases
Context:
- Amodiaquine is an antimalarial drug with a history of poor tolerability and toxicity.
- The World Health Organization (WHO) previously advised against its use due to safety concerns.
Purpose:
- To re-evaluate the therapeutic use of amodiaquine in light of increasing chloroquine resistance.
- To assess the safety and effectiveness of amodiaquine, particularly in combination therapy.
Summary:
- Amodiaquine can cause hematological and hepatic toxicity, partly due to its metabolism by cytochrome P450 CYP2C8 variants.
- Despite toxicity concerns, the WHO now permits amodiaquine use under specific conditions due to rising chloroquine resistance.
- The combination of amodiaquine with artesunate has demonstrated safety and efficacy.
Impact:
- The amodiaquine-artesunate combination is now a recommended first-line treatment for uncomplicated Plasmodium falciparum malaria in 18 African countries.
- This highlights a shift in malaria treatment guidelines, balancing efficacy against resistance with manageable safety profiles.
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