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Updated: Jul 12, 2026

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones
Published on: November 30, 2016
[Composite tumor of the colon with liver metastases]
Jean M Butte1, Javiera Torres, Ignacio Duarte
1Departamento de Cirugía Digestiva, División de Cirugía, Pontificia Universidad Católica de Chile, Marcoleta 367, Santiago, Chile.
Abstract:
Colonic composite tumors are uncommon masses composed of endo- and exocrine cells. Treatment is similar to that of adenocarcinomas. We report the case of a 44-year-old woman who consulted for abdominal pain. A computed tomography (CT) scan showed a tumor at the splenic flexure bowel and 2 hepatic nodules, suggesting metastases. Preoperative biopsies confirmed an adenocarcinoma. The patient underwent surgery, which confirmed the CT findings. Extended right colectomy was performed, followed by an ileal-sigmoid anastomosis, resection of a diaphragm segment, and resection of both hepatic metastases. The patient made a good postoperative recovery. Histological analysis showed moderately differentiated tubular adenocarcinoma combined with a poorly differentiated neuroendocrine carcinoma and metastases in 25 of 28 lymph nodes. The 2 hepatic metastases showed areas of poorly differentiated neuroendocrine carcinoma. The patient is currently asymptomatic and is undergoing chemotherapy.

