Related Experiment Video
Updated: Jul 12, 2026

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
Published on: May 6, 2018
[Psychopathology associated with idiopathic nephrotic syndrome in the pediatric age group]
P J Rodríguez Hernández1, V García Nieto, R García Rodríguez
1Hospital de Día Infantil y Juvenil Diego Matías Guigou y Costa, Servicio de Psiquiatría, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, España. pedrojavierrodriguezhernandez@yahoo.es
Insights
Children with idiopathic nephrotic syndrome (INS) experience more emotional and behavioral problems. Longer disease duration in these children correlates with increased psychological symptoms, highlighting a key factor in their well-being.
Area of Science:
- Pediatric Nephrology
- Child Psychology
- Clinical Pediatrics
Context:
- Idiopathic nephrotic syndrome (INS) is a significant kidney disorder in children.
- Psychological morbidity can impact the quality of life for children with chronic illnesses.
- Understanding these psychological effects is crucial for comprehensive care.
Purpose:
- To investigate psychological morbidity in children diagnosed with idiopathic nephrotic syndrome (INS).
- To compare the psychological well-being of children with INS against a healthy control group.
- To identify specific variables influencing psychological symptoms in pediatric INS.
Summary:
- Children with INS showed significantly higher rates of emotional symptoms and peer problems compared to healthy controls.
- A positive correlation was observed between the duration of the disease and the overall psychological symptom score in the INS group.
- Disease duration emerged as the primary factor associated with the severity of psychological symptoms in children with INS.
Impact:
- This research underscores the heightened risk of emotional and behavioral issues in children with INS.
- Findings suggest that prolonged disease duration is a critical factor to consider when managing psychological health in these patients.
- Highlights the need for integrated psychological support within pediatric nephrology care pathways.
Aim:
To analyze the influence of several variables in the genesis of psychological morbidity in children with idiopathic nephrotic syndrome (INS) as compared with healthy controls.
Methods:
The Strengths and Difficulties Questionnaire (SDQ) was administered to children with INS (n = 23) and a control group of healthy children (n = 38). The SDQ is a well-known screening instrument for psychological/psychiatric morbidity in childhood. The questionnaire consists of five scales that evaluate emotional symptoms, behavioral problems, hyperactivity, peer problems and prosocial behavior. The total score is calculated by adding all the subscales except the prosocial behavior scale. In children with INS, type of treatment, sex, steroid dose, disease stage, disease duration, and prognosis (number of relapses/disease stage) were also noted.
Results:
Statistically significant differences were found in two of the scales (emotional symptoms and peer problems), as well as in the total score in children with INS as compared with the control group (p < 0.05). A positive correlation was found between disease duration and total score in the INS group.
Conclusions:
Emotional and behavioral problems were more frequent in children with INS. The only variable related to the severity of the symptoms studied in these children was disease duration.
Related Concept Videos
Nephrotic Syndrome I : Introduction
Nephrotic Syndrome II : Assessment and Medical Management
Nephrotic Syndrome III : Nursing Management
Nephrons
Pharmacokinetics in Pediatric Patients: Drug Excretion
Chronic Kidney Disease II: Clinical Manifestations
