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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Related Experiment Video

Updated: Jul 12, 2026

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
08:41

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

Bone transport using hydroxyapatite loaded with bone morphogenetic protein in rabbits.

K Watanabe1, H Tsuchiya, K Sakurakichi

  • 1Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa, Japan.

The Journal of Bone and Joint Surgery. British Volume
|September 6, 2007
PubMed
Summary

Bone regeneration is feasible using bone substitutes and essential factors like scaffold and proteins. This study in rabbits demonstrates the viability of bone transport for regenerating bone defects.

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Biological Compatibility Profile on Biomaterials for Bone Regeneration
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Related Experiment Videos

Last Updated: Jul 12, 2026

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
08:41

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
09:09

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection

Published on: March 14, 2019

Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Area of Science:

  • Orthopedic surgery
  • Biomaterials science
  • Regenerative medicine

Background:

  • The efficacy of bone transport using bone substitutes remains unclear.
  • Essential factors for successful bone transport are not well-defined.

Purpose of the Study:

  • To investigate the feasibility of bone transport with bone substitutes.
  • To identify critical factors for successful bone transport and bone regeneration.

Main Methods:

  • Six groups of 12 Japanese white rabbits were used, receiving either autologous bone segments or hydroxyapatite prostheses.
  • Experimental groups varied in the presence of periosteum, blood supply, proteins, and scaffold material.
  • Hydroxyapatite prostheses were either loaded with recombinant human bone morphogenetic protein-2 or used alone.

Main Results:

  • Distraction osteogenesis was observed in groups with osteo-conductive transport segments loaded with osteo-inductive proteins.
  • Successful bone transport and regeneration occurred in groups A (periosteum preserved), B (no blood supply), C (proteins and scaffold), and E (hydroxyapatite with bone morphogenetic protein-2).

Conclusions:

  • Scaffold and proteins are essential components for successful bone transport.
  • Bone substitutes, particularly hydroxyapatite combined with osteo-inductive proteins, can be effectively used for bone regeneration.