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Related Experiment Video

Updated: Jul 12, 2026

Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells

Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells

Published on: August 5, 2016

Brucellosis concomitant with acute leukemia.

Ali Bay¹, Ahmet Faik Oner, Murat Dogan

¹Yuzuncu Yil University Faculty of Medicine, Division of Hematology, Van, Turkey. bayalibay@yahoo.com

Indian Journal of Pediatrics

|September 6, 2007

Summary

This study reports two rare cases of acute leukemia coinciding with brucellosis. Simultaneous treatment for both conditions led to successful remission in both patients, with no observed reactivation.

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Area of Science:

Infectious Diseases
Hematology
Oncology

Background:

Brucellosis and acute leukemia are distinct conditions that can present with overlapping symptoms like fever and cytopenias.
The simultaneous occurrence of brucellosis and acute leukemia has not been previously documented in medical literature.

Observation:

Two patients presented with concurrent brucellosis and acute leukemia, one with generalized arthralgia and pancytopenia, the other with mild leucopenia and thrombocytopenia, both experiencing fever.
Both patients underwent simultaneous chemotherapy for acute lymphoblastic leukemia (ALL) and brucellosis.

Findings:

The first patient's fever resolved within 3 days, while the second patient experienced a subfebrile temperature for 5 days before resolution.
Both patients achieved complete remission of their acute leukemia and showed no signs of brucellosis reactivation during follow-up.

Implications:

This case series highlights the possibility of co-existing brucellosis and acute leukemia, even with similar clinical presentations.
Simultaneous treatment appears effective for managing both conditions, suggesting a need for considering brucellosis in leukemia patients presenting with relevant symptoms.
Further research is warranted to understand the interaction between these two diseases and optimize treatment strategies.