Related Experiment Video
Updated: Jul 12, 2026

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
Published on: September 18, 2017
The cardiometabolic syndrome and calcium channel blocker combination drugs
James R Sowers1, George L Bakris, Henry R Black
1Diabetes Research Center, University of Missouri-Columbia, Columbia, MO, USA.
Abstract:
On April 18, 2007, a panel was convened to discuss the metabolic syndrome and its relationship to the renin-angiotensin system. James R. Sowers, MD, Professor of Medicine and Physiology and Director of the Diabetes Research Center, University of Missouri-Columbia, Columbia, moderated the panel. George L. Bakris, MD, Professor of Medicine, University of Chicago, Chicago, IL; Henry R. Black, MD, Clinical Professor of Internal Medicine, New York University School of Medicine, New York, NY; and Thomas D. Giles, MD, Professor of Medicine, Tulane University School of Medicine, New Orleans, LA, participated in the discussion. This expert panel discussion was supported by Novartis and each author received an honorarium from Novartis for time and effort spent participating in the discussion and reviewing the transcript for important intellectual content prior to publication. The authors maintained full control of the discussion and the resulting content of this article.
Related Concept Videos
Antianginal Drugs: Calcium Channel Blockers and Ranolazine
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
Antihypertensive Drugs: Action of Calcium Channel Blockers
Antiarrhythmic Drugs: Class IV Agents as Calcium Channel Blockers
Verapamil, a calcium channel blocker, inhibits calcium movement across myocardial cell membranes and vascular smooth muscle. This results in the dilation of coronary and...
Antiarrhythmic Drugs: Class I Agents as Sodium Channel Blockers
Class 1A Antiarrhythmic Drugs: These drugs work by moderately blocking sodium channels,...
Antiepileptic Drugs: Calcium Channel Blockers
Calcium channel blockers exert their antiepileptic effects by targeting T-type calcium channels, which are integral to transmitting nerve signals in the central nervous system. These channels allow the passage of calcium ions, which are vital for neuronal communication. By inhibiting T-type calcium channels, calcium channel blockers effectively reduce the release of neurotransmitters and...
Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers