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Elastosis perforans serpiginosa.

Tina Suneja1, Beth Zelonis, M Yadira Hurley

  • 1Denver Dermatology Consultants PC, Denver, CO, USA. toffee108@gmail.com

Skinmed
|September 6, 2007
PubMed
Summary
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This case study describes elastosis perforans serpiginosa, a rare skin condition, in a man with Down syndrome. The diagnosis was confirmed by biopsy showing abnormal elastin extrusion through the epidermis.

Area of Science:

  • Dermatology
  • Histopathology
  • Genetics

Background:

  • Down syndrome is a genetic disorder associated with various dermatological conditions.
  • Elastosis perforans serpiginosa (EPS) is a rare benign reactive perforating disorder of the skin.

Observation:

  • A 41-year-old man with Down syndrome presented with a chronic, pruritic, papular eruption on his forearms.
  • The lesions were characterized by keratotic, umbilicated pink papules in an annular configuration, with surrounding hyperpigmentation and atrophy.

Findings:

  • Histopathological examination revealed extrusion of bright red fibers, identified as abnormal elastin, through an acanthotic epidermis.
  • Special stains confirmed the presence of abnormal elastin, leading to the diagnosis of elastosis perforans serpiginosa.

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Implications:

  • This case highlights a rare cutaneous manifestation in an individual with Down syndrome.
  • Understanding the histopathological features of EPS is crucial for accurate diagnosis and management.
  • Further research may explore potential links between genetic factors in Down syndrome and the development of elastosis perforans serpiginosa.