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Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

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Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
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Published on: June 14, 2021

Graft failure: II. Ocular surface complications.

Samar A Al-Swailem1

  • 1Department of Ophthalmology, King Khaled Eye Specialist Hospital, PO Box 7191, Riyadh 11462, Kingdom of Saudi Arabia. angelofsa@yahoo.com

International Ophthalmology
|September 6, 2007
PubMed
Summary

Ocular surface disorders (OSD) significantly impact corneal transplant success. Addressing OSD pre- and post-operatively is crucial for improving graft survival and visual outcomes in patients undergoing corneal transplantation.

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Area of Science:

  • Ophthalmology
  • Transplantation Immunology
  • Corneal Disease

Background:

  • Corneal transplantation failure is multifactorial, involving immunologic (e.g., graft rejection) and non-immunologic factors.
  • Ocular surface disorders (OSD) and glaucoma are significant non-immunologic risk factors impacting graft survival.
  • Healthy ocular surface epithelia, tear film, and eyelid function are essential for successful corneal grafts.

Purpose of the Study:

  • To review the impact of ocular surface disorders on corneal graft outcomes.
  • To discuss donor and surgical factors influencing ocular surface integrity post-transplant.
  • To explore current and future research for improving corneal transplant success in the presence of OSD.

Main Methods:

  • Literature review of immunologic and non-immunologic risk factors for corneal transplant failure.
  • Analysis of the pathology and impact of various OSD on native and transplanted corneas.
  • Examination of pre- and post-operative medical and surgical strategies.

Main Results:

  • OSD, including their pathology and effects on the ocular surface, are critical determinants of corneal graft success.
  • Donor characteristics and surgical techniques play a role in maintaining ocular surface integrity.
  • Research is ongoing to develop better pre- and post-operative management strategies for OSD.

Conclusions:

  • Optimizing ocular surface health is paramount for successful corneal transplantation.
  • Comprehensive management of OSD, encompassing medical and surgical interventions, is necessary.
  • Future research holds promise for enhancing corneal graft longevity and patient outcomes.