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Regulation of catalytic activity of S6 kinase 2 during cell cycle

Derek Boyer1, Rene Quintanilla, Kay K Lee-Fruman

  • 1Department of Biological Sciences, California State University at Long Beach, Long Beach, CA 90840, USA.

Molecular and Cellular Biochemistry
|September 6, 2007
PubMed

Insights

Ribosomal S6 kinase 2 (S6K2) shows activity throughout the cell cycle, particularly in G2 and M phases. This finding suggests S6K2, like S6K1, may have crucial roles in cell division.

Area of Science:

  • Cell biology
  • Molecular signaling
  • Biochemistry

Background:

  • Ribosomal S6 kinase 2 (S6K2) is regulated by the mTOR pathway and shares homology with S6K1.
  • Despite homology, S6K1 and S6K2 exhibit distinct functions, with S6K2's biological role remaining largely unknown.
  • Understanding S6K2's function is crucial for deciphering its role in cellular processes.

Purpose of the Study:

  • To determine the cell cycle stages where S6K2 exhibits activity.
  • To compare the cell cycle-dependent activity of S6K2 with its homolog, S6K1.

Main Methods:

  • Assessment of S6K2 catalytic activity across different phases of the cell cycle.
  • Monitoring of S6K1 activity during the cell cycle for comparative analysis.

Main Results:

  • S6K2 demonstrates catalytic activity throughout the entire cell cycle.
  • S6K2 activity is notably higher during the G2 and M phases.
  • S6K1 activity exhibits a sharp peak specifically during the M phase.

Conclusions:

  • S6K2 plays a role across the cell cycle, with heightened activity in G2 and M phases.
  • Both S6K1 and S6K2 likely possess uncharacterized functions during the G2 and M phases of the cell cycle.
  • These findings provide a foundation for further investigation into the specific roles of S6K1 and S6K2 in cell division.

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