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Hepatitis G virus exposure in dialysis patients

Ali Eslamifar1, Rasool Hamkar, Amitis Ramezani

  • 1Clinical Research Department, Pasteur Institute of Iran, No 69, Pasteur Ave., Tehran, 13164, Iran.

International Urology and Nephrology
|September 6, 2007
PubMed

Insights

Hepatitis G virus (HGV) exposure was low in Iranian dialysis patients, with only 3.89% of hemodialysis patients testing positive for anti-HGV envelope protein E2. HGV RNA was not detected, suggesting viral clearance in exposed individuals.

Area of Science:

  • Virology
  • Infectious Diseases
  • Nephrology

Background:

  • Hepatitis G virus (HGV) is a blood-borne pathogen primarily transmitted parenterally.
  • Dialysis patients are a potential risk group for blood-borne virus exposure.
  • Assessing HGV prevalence in this population is crucial for understanding transmission dynamics.

Purpose of the Study:

  • To determine the frequency of Hepatitis G virus (HGV) exposure among patients undergoing hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) in Iran.
  • To investigate potential risk factors associated with HGV exposure in this cohort.

Main Methods:

  • A cohort of 77 HD and 13 CAPD patients in Tehran, Iran, were studied.
  • HGV exposure was indicated by the presence of anti-HGV envelope protein E2 (anti-E2) detected via ELISA.
  • HGV RNA was assessed using RT-PCR in anti-E2 positive patients; screening for HBV and HCV markers was also performed.

Main Results:

  • Anti-HGV envelope protein E2 (anti-E2) was detected in 3.89% of hemodialysis patients; no CAPD patients tested positive.
  • Hepatitis G virus (HGV) RNA was not detected in any patient, indicating viral clearance.
  • No co-infection with Hepatitis C virus (HCV) or Hepatitis B virus (HBV) was observed in anti-E2 positive patients.

Conclusions:

  • The rate of Hepatitis G virus (HGV) exposure is low in Iranian dialysis patients.
  • Anti-HGV envelope protein E2 (anti-E2) seropositivity correlated with HGV RNA clearance.
  • HGV exposure showed no significant association with age, sex, blood transfusion history, or dialysis duration.
Abstract

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