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Updated: Jul 12, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Myocardial perfusion defects and coronary risk factors in symptomatic and asymptomatic elderly women

Su Jin Lee1, Kyung-Han Lee, So-Mi Park

  • 1Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwondong, Kangnamgu, Seoul, Korea. suesj@samsung.com

The International Journal of Cardiovascular Imaging
|September 6, 2007
PubMed

Insights

In elderly women, coronary artery disease (CAD) risk factors like diabetes and hypertension increase myocardial ischemia risk, even without symptoms. Pharmacologic perfusion imaging detects this using (201)Tl SPECT.

Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Geriatrics

Background:

  • Investigated the link between coronary artery disease (CAD) risk factors and myocardial ischemia in elderly women.
  • Utilized thallium-201 SPECT ((201)Tl SPECT) for ischemia detection.

Purpose of the Study:

  • To assess the relationship between CAD risk factors and myocardial ischemia in women aged 75 and older.
  • To evaluate the utility of pharmacologic (201)Tl SPECT in identifying ischemia in this demographic.

Main Methods:

  • Included 306 women (mean age 79.1 years) undergoing pharmacologic (201)Tl SPECT for suspected CAD.
  • Evaluated risk factors: diabetes mellitus (DM), hypertension, hypercholesterolemia, smoking, age ≥80, obesity.
  • Quantified ischemia using Summed Stress Score (SSS), Summed Rest Score (SRS), and Summed Difference Score (SDS).

Main Results:

  • Symptomatic group had a 34.5% perfusion defect rate; asymptomatic group had 16.8%.
  • Asymptomatic individuals with diabetes mellitus (DM) or hypertension showed increased defect rates (29.4% and 22.0%).
  • Asymptomatic patients' SSS was comparable to symptomatic patients, indicating similar ischemia severity.

Conclusions:

  • Pharmacologic perfusion imaging effectively identifies myocardial ischemia in elderly women with suspected CAD.
  • This method is valuable for detecting ischemia in both symptomatic patients and asymptomatic individuals with concurrent DM or hypertension.
Abstract

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