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Epidermal growth factor in human tear fluid: a minireview
G B van Setten1, T Tervo, L Viinikka
1Department of Ophthalmology, University of Helsinki, Finland.
International Ophthalmology
|November 1, 1991
Summary
Epidermal growth factor (EGF) is present in human tears, originating from the ocular surface and influenced by tear fluid dynamics. Changes in tear fluid EGF levels during ocular surface diseases may have clinical implications for topical EGF treatments.
Area of Science:
- Ophthalmology
- Cell Biology
- Biochemistry
Background:
- Epidermal Growth Factor (EGF) plays a crucial role in cellular processes, including wound healing and tissue repair.
- Tear fluid composition reflects the health of the ocular surface.
- EGF and its receptors are vital for maintaining ocular surface homeostasis.
Purpose of the Study:
- To review the presence and origin of EGF in human tear fluid.
- To discuss alterations in tear fluid EGF concentrations during ocular surface diseases.
- To explore the clinical implications of topical EGF treatment.
Main Methods:
- Literature review of studies on EGF in human tear fluid.
- Analysis of the relationship between tear fluid dynamics and EGF occurrence.
- Discussion of EGF-EGF receptor interactions in ocular surface diseases.
Main Results:
- EGF is a component of human tear fluid, with its presence influenced by tear dynamics.
- Tear fluid EGF concentrations vary with different ocular surface diseases.
- The interaction between EGF and its receptors is central to understanding these alterations.
Conclusions:
- Tear fluid EGF is a significant biomarker for ocular surface health.
- Understanding EGF dynamics in tears can inform therapeutic strategies.
- Topical EGF treatment holds potential for managing ocular surface conditions.