Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Presynaptic SNAP25 supports maturation of hippocampal mossy fiber-CA3 synapses.

iScience·2026
Same author

Long-term functional synaptic integration of genome-edited retinal organoids in a primate model of macular degeneration.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same author

Role of Upregulated Mucin 21 in Detached Lung Cancer Cells.

Pathology international·2026
Same author

Distinct pathophysiological mechanisms of CEP152 variants in microcephaly and brain abnormalities.

EMBO molecular medicine·2026
Same author

Toward the promotion of One Health - Part II: Interdisciplinary research cooperation between digital transformation and exposome.

The journal of physiological sciences : JPS·2026
Same author

Closer to the native state: Sandwich freezing and freeze-substitution of microorganisms, cultured cells, and animal and plant tissues for electron microscopy.

Journal of microscopy·2026

Related Experiment Video

Updated: Jul 12, 2026

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
11:15

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

Published on: May 6, 2018

Chondrosarcoma with myxoid change: a study using a quick-freezing and deep-etching method.

Akihiro Hemmi1, Shunzo Osaka, Ohni Sumie

  • 1Department of Pathology, Nihon University Nerima Hikarigaoka Hospital, Tokyo, Japan. ahemmi@med.nihon-u.ac.jp

Ultrastructural Pathology
|September 6, 2007
PubMed
Summary

This study reveals that chondrosarcoma

More Related Videos

Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone
09:31

Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone

Published on: April 8, 2015

Rapid Freezing using Sandwich Freezing Device for Good Ultrastructural Preservation of Biological Specimens in Electron Microscopy
09:03

Rapid Freezing using Sandwich Freezing Device for Good Ultrastructural Preservation of Biological Specimens in Electron Microscopy

Published on: July 19, 2021

Related Experiment Videos

Last Updated: Jul 12, 2026

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
11:15

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

Published on: May 6, 2018

Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone
09:31

Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone

Published on: April 8, 2015

Rapid Freezing using Sandwich Freezing Device for Good Ultrastructural Preservation of Biological Specimens in Electron Microscopy
09:03

Rapid Freezing using Sandwich Freezing Device for Good Ultrastructural Preservation of Biological Specimens in Electron Microscopy

Published on: July 19, 2021

Area of Science:

  • Orthopedic Oncology
  • Cancer Biology
  • Biomaterials Science

Background:

  • A middle-aged woman presented with hip pain, diagnosed with an acetabular bone tumor.
  • The tumor was identified as a chondrosarcoma with significant myxoid changes.

Observation:

  • Quick-freezing and deep-etching (QF-DE) microscopy revealed unique extracellular matrix features.
  • The myxoid areas showed a proteoglycan (PG) meshwork lacking aggrecans, similar to normal cartilage pericellular matrix.
  • Thin collagen fibrils with periodic pleats were sparsely distributed, resembling those in normal cartilage's territorial matrix.

Findings:

  • The chondrosarcoma's myxoid matrix composition mirrors that of normal cartilage's pericellular and territorial matrices.
  • Specific proteoglycan (PG) structures and collagen fibril arrangements were identified in the tumor matrix.

Implications:

  • Understanding the matrix composition of chondrosarcoma may offer insights into tumor development.
  • This detailed ultrastructural analysis could inform future therapeutic strategies for bone tumors.
  • The findings highlight the utility of advanced microscopy techniques in characterizing complex biological tissues.