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Updated: Jul 12, 2026

Laboratory Scale Production and Purification of a Therapeutic Antibody
09:54

Laboratory Scale Production and Purification of a Therapeutic Antibody

Published on: January 24, 2017

Immunobiological aspects of therapeutic antibodies and related characterization approaches

Patrick Mengyuan Liu1, Heather Handl, Linglong Zou

  • 1Genentech [corrected] Inc, 1 DNA Way, South San Francisco, CA 94080, USA. liu.patrick@gene.com

Current Opinion in Drug Discovery & Development
|September 6, 2007
PubMed

Antibody therapy is one of the fastest growing areas within the biopharmaceutical field. Immunological properties and biological activity are two of the most critical elements of a therapeutic antibody. The development and validation of analytical approaches provide an appropriate means for antibody immunological characterization, while the emergence of new technologies and advanced biological research and discovery help attain a better understanding of the mechanism of action of antibodies, and therefore facilitate the development of new therapeutic antibodies. This review describes the characteristics of therapeutic antibodies from both immunological and biological perspectives. Recent developments and current implementation of related technologies are discussed.

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