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Sample Preparation for Probe Electrospray Ionization Mass Spectrometry
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Neutral desorption sampling of living objects for rapid analysis by extractive electrospray ionization mass

Huanwen Chen1, Shuiping Yang, Arno Wortmann

  • 1Chemistry Department and Applied Biosciences, ETH Zurich, HCI E 329, 8093 Zürich, Switzerland. chw8868@gmail.com

Angewandte Chemie (International Ed. in English)
|September 6, 2007
PubMed
Abstract

No abstract available in PubMed .

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Electrospray Ionization (ESI) Mass Spectrometry01:12

Electrospray Ionization (ESI) Mass Spectrometry

Higher molecular weight biomolecules are nonvolatile compounds that may decompose before ionizing or vaporizing during mass analysis with conventional electron impact ionization methods. Accordingly, electrospray ionization (ESI) is the favored method for vaporizing and ionizing biomolecules as it circumvents rapid fragmentation and enables the recording of mass signals for the entire biomolecule.
ESI utilizes electrical energy to transfer ions from the liquid phase of the sample into the...

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