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Liposomal amphotericin B in the treatment of visceral leishmaniasis
S L Croft1, R N Davidson, E A Thornton
1Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, UK.
The Journal of Antimicrobial Chemotherapy
|October 1, 1991
Abstract:
A case of visceral leishmaniasis unresponsive to several course of treatment with standard drugs, was successfully cured by a 21 day course (50 mg/day) of liposomal amphotericin B (AmBisome, Vestar Inc.). The efficacy of the AmBisome formulation is supported by experimental studies on Leishmania donovani infected BALB/c mice where ED50 values of AmBisome and conventional amphotericin B were 0.15-0.25 and 0.95-4.9 mg/kg, respectively. A lack of toxicity of the AmBisome formulation was noted in both studies.