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Fast titration experiments using heat conduction microcalorimeters.

M Bastos1, S Hägg, P Lönnbro

  • 1Division of Thermochemistry, University of Lund, Sweden.

Journal of Biochemical and Biophysical Methods
|October 1, 1991
PubMed
Summary
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Thermopile heat conduction calorimeters are slow, requiring hours for fast experiments. A new dynamic correction method speeds up these measurements tenfold without losing accuracy, allowing injections every 1.5 minutes.

Area of Science:

  • Analytical Chemistry
  • Physical Chemistry
  • Chemical Instrumentation

Background:

  • Thermopile heat conduction calorimeters typically exhibit long time constants.
  • This limitation significantly extends the duration of multistep titration experiments, especially those involving rapid chemical processes.

Purpose of the Study:

  • To investigate a method for accelerating titration experiments using thermopile heat conduction calorimeters.
  • To assess the accuracy and efficiency of a dynamic correction method for such experiments.

Main Methods:

  • Development and application of a "dynamic correction method" to thermopile heat conduction calorimetry.
  • Implementation of the method on a new small vessel thermopile conduction calorimeter.

Main Results:

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  • The dynamic correction method enables experiments to be conducted approximately 10 times faster than conventional methods.
  • No loss of accuracy was observed when using the dynamic correction method.
  • Injections in the new calorimeter could be performed at intervals as short as 1.5 minutes.

Conclusions:

  • The dynamic correction method significantly enhances the speed of multistep titration experiments with thermopile heat conduction calorimeters.
  • This advancement allows for more efficient analysis of fast processes without compromising data integrity.
  • The developed small vessel calorimeter with the dynamic correction method offers a faster alternative for kinetic studies.