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[Clinical and epidemiological study on osteofluorosis].

H Kudo1

  • 1Department of Hygiene and Public Health, School of Medicine, Iwate Medical University.

Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
|December 1, 1991
PubMed
Summary

High fluoride exposure, from air or water, can lead to osteofluorosis. This study identified possible cases and key bone changes, emphasizing the need for monitoring environmental fluoride levels.

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Area of Science:

  • Environmental Health
  • Bone Metabolism
  • Toxicology

Context:

  • Osteofluorosis is a bone disease caused by excessive fluoride intake.
  • Long-term exposure to elevated fluoride levels in air or drinking water is a significant risk factor.
  • Understanding the clinical manifestations and diagnostic criteria is crucial for public health.

Purpose:

  • To investigate the clinical signs of osteofluorosis in individuals with prolonged high fluoride exposure.
  • To correlate radiographic bone findings with environmental fluoride levels and biological markers (serum, urine).
  • To identify early indicators of osteofluorosis for improved diagnosis and management.

Summary:

  • A study examined subjects exposed to airborne fluoride (avg. 0.88 mg/m3) and high fluoride drinking water (up to 13 ppm).
  • Possible osteofluorosis was found in 4/63 subjects exposed to airborne fluoride and 19/95 subjects with high fluoride water intake.
  • One definite case of osteofluorosis (Roholm's stage II) was identified in a subject with 26 years of exposure to 12 ppm fluoride in drinking water, showing elevated serum fluoride, ALP, and osteocalcin.
  • Key radiographic findings included lumbar osteophytes, ossification of pelvic and forearm/lower leg interosseous membranes.

Impact:

  • Highlights the link between environmental fluoride contamination and bone pathology.
  • Identifies specific radiographic signs that can aid in the early diagnosis of osteofluorosis.
  • Emphasizes the importance of monitoring fluoride levels in air and water to prevent skeletal fluorosis.

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