Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selecting exposure parameters in developmental neurotoxicity assessments.

B K Nelson1

  • 1National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Science, Cincinnati, OH 45226.

Neurotoxicology and Teratology
|November 1, 1991
PubMed
Summary

Selecting appropriate exposure parameters is crucial for developmental neurotoxicity studies. Key factors include study purpose, pharmacokinetics, biotransformation, and genotypic variables, influencing toxicity from single versus multiple doses.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The ability of spore formers to degrade milk proteins, fat, phospholipids, common stabilizers, and exopolysaccharides.

Journal of dairy science·2019
Same author

Invited review: anaerobic fermentation of dairy food wastewater.

Journal of dairy science·2012
Same author

Flavor profiles of full-fat and reduced-fat cheese and cheese fat made from aged Cheddar with the fat removed using a novel process.

Journal of dairy science·2006
Same author

Yield and aging of Cheddar cheeses manufactured from milks with different milk serum protein contents.

Journal of dairy science·2005
Same author

A microfiltration process to maximize removal of serum proteins from skim milk before cheese making.

Journal of dairy science·2005
Same author

Impact of milk preacidification with CO2 on cheddar cheese composition and yield.

Journal of dairy science·2004

Area of Science:

  • Environmental toxicology
  • Neuroscience
  • Developmental biology

Background:

  • Developmental neurotoxicity (DNT) studies require careful selection of exposure parameters.
  • Factors influencing DNT include the timing, duration, and dose of chemical exposure.
  • Understanding these factors is critical for accurate risk assessment of environmental agents.

Purpose of the Study:

  • To outline essential factors for selecting exposure parameters in DNT investigations.
  • To discuss the interplay between agent properties and organism genetics in determining toxicity.
  • To guide researchers in designing robust DNT studies.

Main Methods:

  • Review of critical factors for DNT study design.
  • Consideration of pharmacokinetics, pharmacodynamics, and biotransformation.

Related Experiment Videos

  • Inclusion of genotypic variables and practical limitations.

    • Main Results:

    • Study purpose, pharmacokinetics/pharmacodynamics, biotransformation, genotypic variables, and limiting factors are primary considerations.
    • The relative toxicity of single high doses versus multiple smaller doses depends on agent properties and organism genetics.
    • A comprehensive approach is needed to address miscellaneous factors.

    Conclusions:

    • Effective DNT study design necessitates a multifaceted approach.
    • Understanding the interaction between chemical properties and host genetics is key to assessing developmental neurotoxic risk.
    • Standardized guidelines for exposure parameter selection are vital for reproducible research.