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[Bone marrow changes in patients with thyroid carcinoma].

A Linden1, R Weiss, K Smolarz

  • 1Klinik und Poliklinik für Nuklearmedizin, Universität zu Köln, FRG.

Nuklearmedizin. Nuclear Medicine
|December 1, 1991
PubMed
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Magnetic resonance imaging (MRI) and bone marrow scintigraphy effectively assess bone marrow expansion in thyroid carcinoma patients. These imaging results showed no significant correlation with clinical or treatment factors.

Area of Science:

  • Oncology
  • Radiology
  • Nuclear Medicine

Background:

  • Thyroid carcinoma can affect bone marrow, necessitating evaluation of its extent.
  • Radioiodine therapy is a common treatment for thyroid cancer, potentially impacting bone marrow.

Purpose of the Study:

  • To evaluate bone marrow expansion in patients with thyroid carcinoma using MRI and bone marrow scintigraphy.
  • To correlate imaging findings with various clinical and treatment parameters.

Main Methods:

  • 79 MRI bone marrow examinations and 48 bone marrow scintigraphies were performed in 62 patients with thyroid carcinoma.
  • Comparison of imaging results with histology, TNM staging, radioiodine therapy doses, and hematological parameters.

Main Results:

Related Experiment Videos

  • MRI and bone marrow scintigraphy yielded comparable results for assessing bone marrow expansion.
  • Bone marrow expansion was observed in a significant portion of patients, extending to the femur and tibia.
  • No significant correlations were found between bone marrow imaging findings and clinical/treatment variables.
  • Bone marrow changes before and after radioiodine therapy (up to 48 GBq 131I) were similar.
  • Malignant infiltration was suspected in 8 patients, with confirmed or presumed metastases.

Conclusions:

  • MRI and bone marrow scintigraphy are reliable methods for assessing bone marrow expansion in thyroid carcinoma.
  • Bone marrow changes in these patients do not appear to be significantly influenced by common clinical and therapeutic factors.
  • Further investigation is warranted for localized findings suggestive of malignant infiltration.