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Plasma levels of soluble glycoprotein 130 in acute myocardial infarction

Tomoko Ichiki1, Michihisa Jougasaki, Manabu Setoguchi

  • 1Institute for Clinical Research, National Hospital Organization Kagoshima Medical Center, Shiroyama-cho 8-1, Kagoshima, Kagoshima 892-0853.

Journal of Cardiology
|September 7, 2007
PubMed
Abstract

Insights

Plasma levels of soluble glycoprotein 130 (sgp130) change during acute myocardial infarction (AMI). Lower sgp130 levels correlate with inflammation markers, suggesting a role in cardiovascular disease.

Area of Science:

  • Biochemistry
  • Immunology
  • Cardiology

Background:

  • Soluble glycoprotein 130 (sgp130) is a receptor subunit for interleukin-6 (IL-6) family cytokines.
  • sgp130 acts as an inhibitory regulator of IL-6 family cytokine signaling.
  • The role of sgp130 in cardiovascular diseases, specifically acute coronary syndrome, is not well understood.

Purpose of the Study:

  • To investigate the role of plasma sgp130 levels in patients with acute myocardial infarction (AMI).
  • To examine the temporal changes in sgp130 levels during the course of AMI.
  • To explore the association between sgp130 levels and markers of inflammation in AMI patients.

Main Methods:

  • Plasma sgp130 levels were measured using enzyme-linked immunosorbent assay (ELISA) in AMI patients and healthy controls.
  • Measurements were taken at admission and at various time points up to 4 weeks post-admission.
  • Correlations with white blood cell count and C-reactive protein levels were analyzed.

Main Results:

  • Plasma sgp130 levels were elevated at admission in AMI patients compared to controls.
  • sgp130 levels decreased significantly between day 2 and day 5 post-admission.
  • Lower sgp130 levels showed an inverse correlation with white blood cell count and peak C-reactive protein levels.
  • In vitro studies suggested that IL-6 and soluble IL-6 receptor can decrease plasma sgp130 levels.

Conclusions:

  • Plasma sgp130 levels are dynamically modulated during the acute phase of myocardial infarction.
  • sgp130 levels are inversely associated with inflammatory markers in AMI.
  • These findings suggest sgp130 plays a role in the inflammatory response associated with AMI.

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