[Role of monoamines in the pathogenesis of various forms of endocrine sterility]

No doubt, the problems of pathogenesis of different types of endocrine sterility are of practical interest. Biogenic amines (dopamine, norepinephrine and serotonin) play a decisive role in the hypothalamic regulation of the sexual cycle, in the regulation of secretion and production of hypothalamic neurohormones. Disorder of the monoaminergic regulation may lie at the basis of reproductive dysfunction. A total of 40 women with hyperprolactinemia, 44 with a hyperandrogenic sterility, 40 with chronic anovulation of obscure genesis, and 20 healthy women of reproductive age (controls) were investigated. The following diagnostic methods were used: echography of the uterus and appendages, x-ray of the cranial bones, laparoscopy, determination of blood levels of FSH, LH, PRL, estradiol, progesterone, testosterone, cortisol in the follicular and luteal phases of the menstrual cycle; determination of urinary levels of dopamine, adrenalin and norepinephrine, and blood levels of serotonin. The results have shown that hyperprolactinemia and hyperandrogenemia are accompanied by disorder of monoaminergic regulation, resulting in the rearrangement of hormonal interrelationships in the neuroendocrine system.