Related Experiment Videos
[Effect of roots of Ficus hirta on cocaine-induced hepatotoxicity and active components]
Qing-yuan Cai1, Hu-biao Chen, Shao-qing Cai
1Department of Natural Medicines, Peking University School of Pharmaceutical Sciences, Beijing 100083, China.
Objective:
To investigate the protective effect of the roots of F. hirta against the cocaine-induced hepatotoxicity and it's active components.
Method:
Cocaine hydrochloride was subcutaneously injected to make male ICR mice liver wounded. Male ICR mice were randomly ig administered with the F. hirta decoction. The dose groups are 100, 200, 300 g x kg(-1) herb materials per body weight. Cocaine hydrochloride was subcutaneously injected into the mice after the administration. The serum ALT, AST activity and the activity of CAT in liver homogenate were assayed, and liver change of pathomorphism was evaluated to prove the effect of the F. hirta decoction on cocaine-induced hepatotoxicity. And the activity of psoralean which was separated from the F. hirta decoction by bioassay-guided fractionation, was proofed in the same method.
Result:
We find that the F. hirta decoction shows a distinct effect on reducing serum transferase. The serum transferase and the content CAT in liver homogenate were dose-related reduced, and the histopathological examination found a significantly change of the liver tissues. And the psoralean, qua the mainly component, shows the same effect.
Conclusion:
F. hirta has the protective effect against the cocaine-induced hepatotoxicity. Psoralean is the basis.
Related Concept Videos
Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug
Drug Toxicity: Risk factors
Drug Toxicity: Overview
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
Hepatic Drug Excretion: Influencing Factors
Drug Toxicity: Dose-Dependent Reactions