Biosynthesis and physio-pharmacological actions of angiotensin peptides: 2. Physio-pharmacological properties

The classic concept of the renin-angiotensin system being substantially accomplished by the new cognitive and applicative acquisitions, a natural reconsideration and completion is imposed. In consequence, ample referrals are made to the main central and peripheral actions of Angiotensins through specific receptors. Emphasis is given to the effects of Angiotensin IV and Angiotensin 1-7 which are different of those of Angiotensin II, underlining their possible role as counteracting factors to its actions, in order to remove the imbalances created by the predominating stimulation of vasoconstricting AT, receptors. There are also taken into account the mainly central neural actions of Angiotensin IV, while Angiotensin 1-7 seems to be active only in the periphery. At the end are mentioned the results of our own research on the vasodilating effects of Angiotensin 1-7 and its interrelations with Angiotensin II. New experimental proofs are brought both in favor of the endocrine, paracrine and autocrine role of the circulating and tissue renin-Angiotensin system and of the counteracting of the effects of Angiotensin II by a part of its metabolism products.