[Intolerance to antituberculous drugs and methods of its elimination]

The frequency of adverse reactions to antituberculous drugs was 33.6%, according to the materials of mass screening of Group I contingents of the dispensary record (259 patients) at various levels of treatment (hospital, polyclinic, sanatorium). At the polyclinic level which in all cases was nearly used after hospital, the frequency of adverse reactions was half as much as at the hospital level which was due to the use of the intermittent method and, in most cases, at least 2 drugs. The abolishing action of sodium thiosulphate, splenin, hyperbaric oxygenation and their various combinations was found to be higher than that of antihistaminics used in allergic reactions, hemodez or a 5% glucose solution applied in toxic reactions. Hemosorption and hyperbaric oxygenation are more effective for the alleviation of adverse reactions than splenin and sodium thiosulphate. Toxic reactions are better arrested by hemosorption and sodium thiosulphate, while the allergic reactions by hyperbaric in combination with splenin, sodium thiosulphate or hemosorption.