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Related Experiment Videos

[Black tongue].

Alexey Naimushin1, Avi Livneh

  • 1Medicine F, Sheba Medical Center, Tel Hashomer, Israel.

Harefuah
|September 7, 2007
PubMed
Summary
This summary is machine-generated.

Ceftriaxone, an antibiotic, may cause black tongue by increasing melanin in mouth membranes. This rare side effect resolved after discontinuing the medication.

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Area of Science:

  • Pharmacology
  • Dermatology
  • Oral Medicine

Background:

  • Sjogren syndrome patients may experience various side effects from medications.
  • Urinary tract infections are common and treated with antibiotics like ceftriaxone.
  • Black hairy tongue (lingua villosa nigra) has multiple known causes, including medications.

Observation:

  • A patient with Sjogren syndrome developed black tongue within 20 minutes of intravenous ceftriaxone administration.
  • The black discoloration of the lips and tongue resolved within 24 hours after discontinuing ceftriaxone.
  • The patient had a similar reaction previously after local anesthetic injection.

Findings:

  • Ceftriaxone is a potential new cause of black tongue.
  • The mechanism is hypothesized to involve overproduction or rapid accumulation of melanin in oral mucous membranes.

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  • This contrasts with typical causes like fungal infections or external pigment deposition.

    • Implications:

    • Clinicians should consider ceftriaxone as a potential cause of black tongue.
    • Further investigation is needed to confirm the link between ceftriaxone and melanin-induced black tongue.
    • Awareness of this rare adverse drug reaction is important for patient management.