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Photoelectron Imaging of Anions Illustrated by 310 Nm Detachment of F−
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Published on: July 27, 2018

Desorption atmospheric pressure photoionization.

Markus Haapala1, Jaroslav Pól, Ville Saarela

  • 1Division of Pharmaceutical Chemistry, Faculty of Pharmacy, P.O. Box 56, FI-00014 University of Helsinki, Finland.

Analytical Chemistry
|September 7, 2007
PubMed
Summary

Desorption atmospheric pressure photoionization (DAPPI) enables rapid surface analysis using a heated solvent jet and photoionization. This ambient ionization technique offers sensitive detection, even for less polar compounds, and direct pharmaceutical analysis from tablets.

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Area of Science:

  • Analytical Chemistry
  • Mass Spectrometry
  • Surface Analysis

Background:

  • Ambient ionization techniques are crucial for rapid chemical analysis.
  • Existing methods like desorption electrospray ionization have limitations.
  • Need for sensitive and versatile surface analysis methods.

Purpose of the Study:

  • Introduce and demonstrate Desorption Atmospheric Pressure Photoionization (DAPPI).
  • Evaluate DAPPI's capability for rapid analysis of diverse compounds on surfaces.
  • Compare DAPPI performance with established techniques.

Main Methods:

  • Utilized a heated nebulizer microchip to deliver vaporized solvent (e.g., toluene).
  • Employed a photoionization lamp emitting 10-eV photons for analyte ionization.
  • Analyzed samples directly from surfaces, directing desorbed and ionized analytes into a mass spectrometer.

Main Results:

  • Achieved limits of detection in the range of 56-670 femtomoles (fmol).
  • Successfully demonstrated direct pharmaceutical analysis from tablet surfaces.
  • Showed DAPPI to be equally or more sensitive than desorption electrospray ionization, particularly for less polar analytes.

Conclusions:

  • DAPPI is an effective ambient ionization technique for rapid surface analysis.
  • The method offers high sensitivity and broad applicability across different polarities.
  • DAPPI presents a valuable alternative for surface-based mass spectrometry analyses.