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Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer

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Pulmonary pleomorphic carcinoma producing hCG.

Hiroshi Hirano¹, Toshimi Yoshida, Toshihito Sakamoto

¹Department of Pathology, Nippon Steel Hirohata Hospital, Himeji, Japan. h_hirano@hirohata-hp.or.jp

Pathology International

|September 7, 2007

Summary

Pleomorphic carcinoma (PC) producing hCG in breast cancer patients indicates a higher risk of metastasis. Early-stage PC with hCG expression shows aggressive behavior, leading to poor patient outcomes.

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Area of Science:

Oncology
Pathology
Immunohistochemistry

Background:

A case study of an 80-year-old woman with a history of breast cancer.
The patient presented with an abnormal CT shadow during follow-up.

Observation:

A rapidly growing mass was surgically removed, revealing a 4.8 x 4.0 cm tumor.
Histology showed a pleomorphic carcinoma (PC) with spindle and polygonal cells.
Immunohistochemistry confirmed human chorionic gonadotropin (hCG) expression in approximately 20% of tumor cells.

Findings:

The PC was diagnosed based on its histological features and hCG expression.
Despite early-stage diagnosis (1B) and chemotherapy, the patient developed liver and adrenal metastases within 6 months.
The patient succumbed to metastatic disease 1 year post-operation.

Implications:

Pleomorphic carcinoma with hCG expression is associated with an elevated risk of local recurrence and distant metastasis.
Immunohistochemical detection of hCG in PC may serve as a prognostic marker for aggressive disease.
This case highlights the aggressive nature of hCG-producing PC and the need for vigilant monitoring and potentially novel therapeutic strategies.