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A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

Arterial thromboembolic disease: a single-centre case series study

Paul Monagle1, Fiona Newall, Chris Barnes

  • 1Department of Clinical Haematology, Royal Children's Hospital, University of Melbourne, Melbourne, Victoria, Australia.

Journal of Paediatrics and Child Health
|September 7, 2007
PubMed

Insights

Arterial thromboembolism (TE) in children is as common as venous TE, often linked to surgery. Many survivors experience significant long-term complications, highlighting the need for further research and management strategies.

Area of Science:

  • Pediatric Cardiology
  • Pediatric Neurology
  • Pediatric Surgery

Background:

  • Paediatric venous thromboembolism (TE) incidence has risen, yet arterial TE in children remains understudied.
  • Understanding the pathophysiology, diagnosis, and outcomes of paediatric arterial TE is crucial.

Purpose of the Study:

  • To investigate the prevalence, causes, diagnostic methods, treatment, and outcomes of arterial thromboembolism (TE) in a tertiary pediatric setting.

Main Methods:

  • A prospective, single-centre registry was utilized at an Australian tertiary pediatric center.
  • Data collection covered 48 months, documenting arterial thrombotic events in pediatric patients.

Main Results:

  • 102 arterial TE events occurred in 98 patients; lower limb TE was common in infants, CNS TE in children.
  • Surgery was a frequent predisposing factor; Doppler ultrasonography, CT, and MRI were key diagnostic tools.
  • Mortality was 4% in infants and 9% in children; 49% of survivors had long-term sequelae.

Conclusions:

  • Arterial TE occurs with similar frequency to venous TE in the pediatric population.
  • The clinical outcomes and long-term sequelae associated with paediatric arterial TE are substantial.
Abstract

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