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Updated: Jul 12, 2026

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
Published on: June 2, 2015
Arterial thromboembolic disease: a single-centre case series study.
Paul Monagle1, Fiona Newall, Chris Barnes
1Department of Clinical Haematology, Royal Children's Hospital, University of Melbourne, Melbourne, Victoria, Australia.
Arterial thromboembolism (TE) in children is as common as venous TE, often linked to surgery. Many survivors experience significant long-term complications, highlighting the need for further research and management strategies.
Area of Science:
- Pediatric Cardiology
- Pediatric Neurology
- Pediatric Surgery
Background:
- Paediatric venous thromboembolism (TE) incidence has risen, yet arterial TE in children remains understudied.
- Understanding the pathophysiology, diagnosis, and outcomes of paediatric arterial TE is crucial.
Purpose of the Study:
- To investigate the prevalence, causes, diagnostic methods, treatment, and outcomes of arterial thromboembolism (TE) in a tertiary pediatric setting.
Main Methods:
- A prospective, single-centre registry was utilized at an Australian tertiary pediatric center.
- Data collection covered 48 months, documenting arterial thrombotic events in pediatric patients.
Main Results:
- 102 arterial TE events occurred in 98 patients; lower limb TE was common in infants, CNS TE in children.
- Surgery was a frequent predisposing factor; Doppler ultrasonography, CT, and MRI were key diagnostic tools.
- Mortality was 4% in infants and 9% in children; 49% of survivors had long-term sequelae.
Conclusions:
- Arterial TE occurs with similar frequency to venous TE in the pediatric population.
- The clinical outcomes and long-term sequelae associated with paediatric arterial TE are substantial.
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