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Updated: Jul 12, 2026
04:04
Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
Chemotherapy for recurrent cervical cancer.
Isabelle Cadron1, Toon Van Gorp, Frederic Amant
1Division of Gynecological Oncology, Department of Obstetrics and Gynecology, University Hospitals Leuven, Gasthuisberg, B-3000 Leuven, Katholieke Universiteit Leuven, Belgium.
Gynecologic Oncology
|September 7, 2007
Summary
Single agent cisplatin is the standard for recurrent cervical cancer. While cisplatin and topotecan showed improved survival in one study, platinum resistance may affect results, necessitating further research into new chemotherapy and targeted agents.
Area of Science:
- Gynecologic Oncology
- Medical Oncology
- Pharmacology
Background:
- Recurrent cervical cancer presents a significant clinical challenge with limited treatment options.
- Chemotherapy plays a crucial role in managing advanced and recurrent stages of the disease.
Purpose of the Study:
- To review and summarize current chemotherapy regimens for recurrent cervical cancer.
- To evaluate the efficacy and limitations of existing treatment strategies.
Main Methods:
- A comprehensive literature search was conducted using PubMed.
- Keywords included "chemotherapy" and "recurrent cervical cancer".
- Articles published up to April 2007 were included.
Main Results:
- Single-agent cisplatin (50 mg/m2) is identified as the current standard of care.
- Most tested chemotherapeutic agents have not demonstrated improved survival rates.
- The GOG 179 study indicated improved survival with cisplatin and topotecan combination therapy.
Conclusions:
- The benefit observed with cisplatin and topotecan may be influenced by prior platinum exposure and patient population characteristics.
- Platinum resistance is a potential factor affecting treatment outcomes.
- Future research focusing on novel single or doublet chemotherapy regimens and molecular-targeted agents is warranted.
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