Related Experiment Video
Updated: Jul 12, 2026
05:44
Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Unexpected differences in dissolution behavior of tablets prepared from solid dispersions with a surfactant
H de Waard1, W L J Hinrichs, M R Visser
1Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. h.de.waard@rug.nl
International Journal of Pharmaceutics
|September 7, 2007
Summary
Adding sodium lauryl sulphate (SLS) to sugar glass solid dispersions significantly improved drug dissolution rates for poorly soluble drugs. This prevents crystallization, enhancing drug delivery performance.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Drug Delivery
Background:
- Poorly soluble drugs (BCS class II) benefit from increased dissolution rates using sugar glass solid dispersions.
- Previous methods showed limitations with high drug loads or fast-dissolving sugars, leading to drug crystallization.
- Uncontrolled crystallization hinders the effectiveness of drug delivery systems.
Purpose of the Study:
- To investigate the impact of incorporating sodium lauryl sulphate (SLS) into sugar glass solid dispersions to improve drug dissolution.
- To compare the effects of incorporating SLS within the sugar glass versus physically mixing it.
- To elucidate the mechanism behind the observed differences in dissolution behavior.
Main Methods:
- Preparation of solid dispersions with model drugs (diazepam, fenofibrate) and sugar glass, with and without SLS.
- Evaluation of drug dissolution rates for tablets made from these solid dispersions.
- Differential Scanning Calorimetry (DSC) to characterize the solid dispersions and identify interactions.
Main Results:
- Tablets with incorporated SLS showed significantly improved dissolution behavior.
- Tablets from physical mixtures of SLS and solid dispersion exhibited initially fast but then slowed dissolution.
- DSC analysis revealed interactions between SLS, drug, and sugar when SLS was incorporated into the solid dispersion.
Conclusions:
- Incorporating SLS into sugar glass solid dispersions effectively enhances drug dissolution rates.
- Interactions between SLS, drug, and sugar appear to slow SLS dissolution, maintaining high drug solubility near the tablet.
- This approach successfully prevents uncontrolled drug crystallization, optimizing drug delivery.
Related Concept Videos
01:28Factors Influencing Drug Absorption: Pharmaceutical Parameters
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
01:23Factors Affecting Dissolution: Particle Size and Effective Surface Area
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...
01:21Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
01:09Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model
Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the concentration...
01:20Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
01:14Drug Dissolution: Requirements and Profile Comparison
The acceptance criteria for dissolution profile data are anchored in Q values, representing the percentage of drug dissolved within a specified period. This assessment unfolds in three stages:First Stage: The test passes if all six drug dosage units are equal to or greater than Q plus 5%; otherwise, the sample proceeds to the second stage.Second Stage: The average of twelve units must be equal to or greater than Q, with no unit falling below Q - 15% to pass; if not, it progresses to the final...