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Related Experiment Videos

Magnesium-maintained self-administration responding in cocaine-trained rats.

K M Kantak1, S I Lawley, S J Wasserman

  • 1Department of Psychology, Boston University, MA 02215.

Psychopharmacology
|January 1, 1991
PubMed
Summary

Magnesium chloride (MgCl2) shows stimulant properties and can substitute for cocaine in rats, maintaining self-administration behavior. However, it demonstrates lower reinforcing efficacy and abuse potential compared to cocaine.

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Area of Science:

  • Neuroscience
  • Behavioral Pharmacology
  • Psychopharmacology

Background:

  • Magnesium chloride (MgCl2) exhibits behavioral effects analogous to psychomotor stimulants.
  • Previous observations suggest MgCl2 possesses stimulant properties, warranting further investigation into its behavioral effects.

Purpose of the Study:

  • To investigate the reinforcing efficacy of magnesium chloride (MgCl2) in a rat self-administration paradigm.
  • To determine if MgCl2 can substitute for cocaine self-administration under various experimental conditions.

Main Methods:

  • Cocaine-trained rats were subjected to self-administration tasks with varying access periods to MgCl2.
  • Different fixed ratio (FR1, FR5) and progressive ratio (PR) schedules of drug delivery were employed.
  • Experiments assessed MgCl2's ability to maintain responding with and without concurrent cocaine availability.

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Main Results:

  • Magnesium chloride (MgCl2) dose-dependently maintained responding, indicating substitution for cocaine.
  • Responding for MgCl2 persisted over 10 days, even after cocaine availability was removed.
  • Progressive ratio breakpoints for MgCl2 were higher than saline but lower than cocaine, suggesting moderate reinforcing efficacy.

Conclusions:

  • Magnesium chloride (MgCl2) possesses reinforcing properties in cocaine-trained rats, particularly under FR1 and FR5 schedules.
  • While MgCl2 shows some abuse potential, it is significantly lower compared to cocaine.
  • These findings support MgCl2's potential as a substitute for cocaine with a reduced risk profile.