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Updated: Jul 12, 2026

Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
Published on: June 23, 2026
Synthesis and pharmacological profile of serofendic acids A and B
Taro Terauchi1, Naoki Asai, Takashi Doko
1Tsukuba Research Laboratories, Eisai Co., Ltd, Tsukuba-shi 300-2635, Japan. t-terauchi@hhc.eisai.co.jp
Abstract:
We present efficient syntheses of serofendic acids A and B (SA-A and SA-B), novel neuroprotective substances isolated from fetal calf serum. Biological and pharmacological evaluation showed that SA-A and SA-B have potent protective action against glutamate-induced neurotoxicity, but do not interact directly with glutamate receptors. A pharmacokinetic study showed that they have good oral bioavailability in rats. The results indicate that SA-A and SA-B are potential lead compounds for candidate drugs to treat various neurological disorders.
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