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Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis
Published on: September 26, 2012
Autoantibodies against glial antigens in paraneoplastic neurological diseases
M Tschernatsch1, O Gross, N Kneifel
1Department of Neurology, Justus-Liebig-University, Am Steg 14, 35385 Giessen, Germany. Marlene.Tschernatsch@neuro.med.uni-giessen.de
Abstract:
Paraneoplastic neurological syndromes are clinically heterogeneous manifestations of cancer, but are not caused by the tumor or its metastases. Because autoantibodies reacting with tumor and nervous system tissue have been described, an autoimmune pathogenesis is suspected. Most autoantibodies are directed against neuronal proteins. Here, we describe the impact of antiglial autoantibodies in paraneoplastic neurological syndromes. Anti-CRMP5 and antiglial nuclear antibody both can be associated with different paraneoplastic neurological syndromes and tumors.
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