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State changes rapidly modulate cortical neuronal responsiveness.

Andrea Hasenstaub1, Robert N S Sachdev, David A McCormick

  • 1Department of Neurobiology, Kavli Institute of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|September 7, 2007
PubMed
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Cortical neuron responsiveness changes with network activity. Increased activity enhances responses to some stimuli but decreases others, altering sensory information representation.

Area of Science:

  • Neuroscience
  • Computational Neuroscience

Background:

  • Cortical neuron responsiveness is dynamically modulated by local network activity levels.
  • Changes in network activity influence neuronal responses to different stimuli, including intracellular conductance injections and external whisker deflections.

Purpose of the Study:

  • To investigate how varying levels of cortical network activity impact neuronal responsiveness to whisker stimulation.
  • To elucidate the mechanisms underlying state-dependent changes in sensory processing within the somatosensory cortex.

Main Methods:

  • Electrophysiological recordings in rodent somatosensory cortex.
  • Analysis of neuronal responses to controlled intracellular conductance stimuli and naturalistic whisker deflections.
  • Characterization of postsynaptic potentials and network activity states (Up and Down states).

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Main Results:

  • Increased network activity enhanced responsiveness to intracellular stimuli but paradoxically decreased it to brief whisker deflections.
  • Stimulus-evoked increases in circuit activity correlated with greater evoked conductance and action potential responsiveness.
  • During high network activity (Up state), whisker stimuli evoked postsynaptic potentials with increased inhibition, suggesting enhanced inhibitory mechanism efficiency.
  • Prolonged whisker stimulation during increased network activity led to heightened responsiveness, dynamic range, output gain, and better correlation with stimulus speed.

Conclusions:

  • Stimulus-evoked or spontaneous alterations in cortical state significantly and complexly influence neuronal responsiveness.
  • These state-dependent changes result in substantial modifications in the representation of sensory stimuli within the cortex.